- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IP, IHC
- 特异性:Human, Mouse; other species not tested.
PCM1 antibody
产品详情
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产品名称
PCM1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
PCM1 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HT-1080 cells, NIH/3T3 cells. Positive IP detected in HeLa cells. Positive IHC detected in human tonsillitis tissue. Observed molecular weight by Western-blot: 260-270 kDa
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抗体应用
ELISA, WB, IP, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
hPCM 1, PCM 1, PCM1, pericentriolar material 1, PTC4
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制备方法
This antibody was obtained by immunization of PCM1 recombinant protein (Accession Number: NM_001352660). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
Pericentriolar material 1 (PCM1) is a component of centriolar satellites, which are electron dense granules scattered around centrosomes (PMID: 10579718). PCM1 is required for centrosome assembly and function. It acts as a scaffold to target several proteins to the centrosome in a dynein motor-dependent manner and regulate microtubular dynamics (PMID:18762586; 12403812). It is also involved in the biogenesis of cilia (PMID: 18772192). Chromosomal aberrations involving PCM1 gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. (PMID: 10980597; 16091753; 15805263; 16424865).
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