重组小鼠Il4蛋白

产品详情

  • 产品名称
    重组小鼠Il4蛋白
  • 蛋白种属
    小鼠
  • 表达宿主
    大肠杆菌
  • Unitprot ID
    P07750
  • 克隆构建
    A DNA sequence encoding the Mouse Il4/Il-4 His23-Ser140 is expressed.
  • 蛋白纯度
    >95% as determined by SDS-PAGE.
  • 蛋白别名
    Il-4
  • 蛋白全名
    interleukin 4(Il4)
  • 蛋白描述
    Mouse Interleukin-4(IL-4) is a monomeric, Th2 cytokine that shows pleiotropic effects during immune responses. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α­helix structure. IL­4 exerts its effects through two receptor complexes, Participates in at least several B-cell activation processes as well as of other cell types. IL­4 is primarily expressed by Th2­biased CD4+T cells, mast cells, basophils, and eosinophils. It promotes cell proliferation, survival, and immunoglobulin class switch to IgG1 and IgE in mouse B cells, acquisition of the Th2 phenotype by naïve CD4+T cells, priming and chemotaxis of mast cells, eosinophils, and basophils, and the proliferation and activation of epithelial cells. IL­4 plays a dominant role in the development of allergic inflammation and asthma. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
  • 发货形式
    Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.
  • 内毒素
    <1.0 EU per μg protein as determined by the LAL method.
  • 保存条件
    Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
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