Cathelin-related antimicrobial peptide has Antibacterial activity. The source of Cathelin-related antimicrobial peptide is Mus musculus [Mouse]. The CRAMP protects the mouse colon from inflammation, cancer, and microbiome disruption. Studies using conditional knockout mice reveal that epithelial cell-derived CRAMP supports colon crypt development, mucus production, and mucosal repair. Conversely, myeloid cell-derived CRAMP enhances epithelial resistance to bacterial invasion during inflammation but exacerbates mucosal damage and mortality. Current studies highlight the coordinated effects of epithelial and myeloid CRAMP in maintaining colon mucosal homeostasis.