Recombinant Human SLC30A8 Fragment (267-369) - A high-quality recombinant protein representing a stable and soluble fragment of the proton-coupled zinc antiporter SLC30A8 (ZnT-8), specifically engineered for structural and biochemical research applications.

SLC30A8 (Zinc transporter 8) is a proton-coupled zinc ion antiporter that mediates zinc entry into the lumen of pancreatic beta cell secretory granules, playing a critical role in regulating insulin secretion. The full-length protein localizes to cytoplasmic vesicle and secretory vesicle membranes, as well as the cell membrane, where it functions as a multi-pass membrane protein associated with insulin and glucagon secretory granules. This transporter is essential for maintaining zinc homeostasis in pancreatic beta cells, making it a protein of significant interest in diabetes research and metabolic studies.