Xentry is a new class of cell-penetrating peptide, hepatitis B virus. Xentry permeates adherent cells using syndecan-4 as a portal for entry, and is uniquely restricted from entering syndecan-deficient, non-adherent cells, such as resting blood cells. Xentry represents a new class of CPP with properties that are potentially advantageous for life science and therapeutic applications.
Montrose K, Yang Y, Sun X, Wiles S, Krissansen GW. Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs. Sci Rep. 2013;3:1661. doi: 10.1038/srep01661. PMID: 23588666; PMCID: PMC3627194.