Recombinant Human WIPF1 Protein Fragment (residues 416-503) is a high-purity, stable protein fragment derived from the WAS/WASL-interacting protein family member 1. This fragment is ideal for structural studies, biochemical assays, and investigating actin cytoskeleton dynamics, offering researchers a soluble and well-characterized tool for exploring WIPF1's functional domains.

The full-length WIPF1 protein plays a critical role in actin cytoskeleton reorganization by interacting with proteins such as NCK1, GRB2, and WASL. It facilitates the recruitment and activation of WASL, promoting the disassembly of stress fibers and formation of filopodia and cell ruffles. WIPF1 also supports intracellular vaccinia virus motility by acting as an adapter for WASL recruitment. Subcellularly, it localizes to cytoplasmic vesicles, the cytoskeleton, and cell ruffles, and can shift to perinuclear and cortical regions when coexpressed with WASL. The provided fragment (residues 416-503) represents a stable, soluble region selected for structural and functional analyses, enabling focused investigation into WIPF1's mechanisms.