This recombinant protein product features a specific fragment (amino acids 928-1156) of the human E2/E3 hybrid ubiquitin-protein ligase UBE2O, encompassing the UBC core domain. It is engineered to support studies on ubiquitin-conjugating enzyme activity, protein ubiquitination mechanisms, and domain-specific functional assays, providing researchers with a precise tool for targeted experimental applications.

The full-length UBE2O protein is an E2/E3 hybrid ubiquitin-protein ligase with dual enzymatic activities, mediating monoubiquitination of target proteins such as SMAD6 to regulate BMP7 signaling and adipogenesis, and BAP1 to influence its subcellular localization. It also plays roles in modulating TRAF6-mediated NF-kappa-B activation and assisting in retrograde transport via 'Lys-63'-linked ubiquitination. UBE2O is primarily localized in the cytoplasm but can also be found in the nucleus, where it affects the localization of chromatin-associated proteins. This fragment, containing the UBC core dom