TPX2 Polyclonal Antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:WB, IHC
  • 特异性:Human

产品详情

  • 产品名称
    TPX2 Polyclonal Antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    Polyclonal antibody to TPX2
  • 抗体应用
    WB, IHC
  • 应用推荐
    WB 1:500 - 1:2000
    IHC 1:50 - 1:200
  • 特异性
    Human
  • 蛋白别名
    TPX2, C20orf1, C20orf2, DIL-2, DIL2, FLS353, GD:C20orf1, HCA519, HCTP4, REPP86, p100, targeting protein for Xklp2
  • 制备方法
    Antigen: A synthetic peptide of human TPX2
  • 组分
    PBS with 0.02% sodium azide, pH7.3.
  • 储存方法
    Store at 4℃. Avoid freeze / thaw cycles.
  • 背景介绍
    Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
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