The source of TLQP-62 is Rattus norvegicus. TLQP-62 belongs to VGF. TLQP-62 is expressed in Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
The C-terminal peptide TLQP-62 is of particular relevance to maladaptive mechanisms of chronic pain as it is a known mediator of neuroplasticity in the hippocampus affecting learning, memory, depression, and adult neurogenesis.
Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, et al. Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury. Mol Pain. 2008
Skorput AGJ, Zhang X, Waataja JJ, Peterson CD, Riedl MS, Kitto KF, Truong H, Huffman C, Salton SR, Fairbanks CA, Honda CN, Vulchanova L. Involvement of the VGF-derived peptide TLQP-62 in nerve injury-induced hypersensitivity and spinal neuroplasticity. Pain. 2018 Sep;159(9):1802-1813. doi: 10.1097/j.pain.0000000000001277.