C-terminal amidated. Giacometti et al (2006) found that the peptide showed the high activity when used with beta-lactams. As the most active peptide in the temporin family, it may form pore-like openings on cellular membranes (Biochem J 2002; 368: 91-100). A helical structure was found by NMR studies in SDS and DPC micelles (Carotenuto et al. 2008. J Med Chem 51: 2354-62). Temporin L showed synergism with temporins A & B to inhibit LPS aggregation (J Biol Chem. 2006 Sep 29;281(39):28565-74). Temporin L has Antibacterial activity. Temporin L was found in European common frog, Rana temporaria.
储存指南
一般情况下, Temporin L 多肽 粉末应该保存在-20甚至-70摄氏度. Temporin L 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Simmaco M, Mignogna G, Canofeni S, Miele R, Mangoni ML, Barra D. Temporins, antimicrobial peptides from the European red frog Rana temporaria. Eur J Biochem. 1996;242(3):788-92.