产品详情
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产品名称
重组人TEAD4蛋白
- 文档
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蛋白种属
人
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表达宿主
大肠杆菌
- Unitprot ID
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蛋白序列
MSKIKHHHHHHGGSPAPPWQGRSVASSKLWMLEFSAFLEQQQDPDTYNKHLFVHIGQSSPSYSDPYLEAVDIRQIYDKFPEKKGGLKDLFERGPSNAFFLVKFWADLNTNIEDEGSSFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYSYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
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克隆构建
DNA encoding 210-434 aa (Q15561) were fused with N-terminal 6His tag.
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蛋白纯度
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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蛋白活性
Not tested.
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分子量
Predictes a molecular mass of 27.74 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 28 kDa band.
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蛋白全名
Transcriptional enhancer factor TEF-3
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蛋白描述
Recombinant Human TEAD4 Protein Fragment (aa 210-434) is a high-quality, stable, and soluble protein designed for structural and biochemical studies. This fragment of the Transcriptional enhancer factor TEF-3 (TEAD-4) is ideal for investigating its role in the Hippo signaling pathway, which regulates cell proliferation, migration, and organ size control.
The full-length TEAD4 protein, encoded by the TEAD4 gene in Homo sapiens, is a key transcription factor in the Hippo signaling pathway. This pathway is crucial for organ size regulation and tumor suppression by inhibiting proliferation and promoting apoptosis. TEAD4 mediates gene expression driven by YAP1 and WWTR1/TAZ, influencing processes such as epithelial-mesenchymal transition (EMT). It binds specifically to DNA motifs like Sph, GT-IIC, and M-CAT to activate transcription. TEAD4 is localized in the nucleus, underscoring its direct role in gene regulation. The provided fragment (aa 210-434) was selected for its stability and solubility, enabling
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检测结果
Recombinant TEAD4 protein (His tag) SDS-PAGE
M: Marker; Lane 1: TEAD4; Lane 2: BSA
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发货形式
Lyophilized from sterile PBS, pH 7.4
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内毒素
Not tested.
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保存条件
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.