Recombinant Human TEAD-1 (Transcriptional enhancer factor TEF-1) Fragment (aa 202-426) is a high-quality, stable protein fragment designed for structural and biochemical studies. This 225-amino acid fragment retains key functional characteristics, making it an ideal tool for investigating the Hippo signaling pathway, transcriptional regulation, and cellular processes such as proliferation and migration.

TEAD-1, encoded by the TEAD1 gene, is a critical transcription factor in the Hippo signaling pathway, which regulates organ size, tumor suppression, and cellular homeostasis by controlling proliferation and apoptosis. It functions by binding to specific DNA motifs like SPH and GT-IIC enhansons, mediating gene expression driven by YAP1 and WWTR1/TAZ, thereby influencing cell migration and epithelial-mesenchymal transition. TEAD-1 is also involved in cardiac development and is localized to the nucleus, underscoring its role in transcriptional activation. This recombinant fragment provides a soluble and stable unit for detailed mechanistic studies.