This product is a recombinant fragment of the human T-box transcription factor T (Brachyury protein), encompassing amino acids 40-223. This 184-residue fragment is engineered for stability and solubility, making it an ideal tool for structural studies and biochemical assays focused on mesoderm formation and transcriptional regulation.

The full-length Brachyury protein, encoded by the TBXT gene, is a key transcription factor involved in mesoderm formation and differentiation. It functions by binding to the palindromic T-site DNA sequence (5'-TTCACACCTAGGTGTGAA-3') to activate transcription of genes critical for embryonic development. The protein is localized to the nucleus, where it exerts its regulatory role. This fragment was selected computationally to provide a stable, soluble unit that retains utility for investigating the protein's functional mechanisms without containing known domains, facilitating research into its structural and interaction properties.