The transactivating transcriptional activator (TAT) peptide, a cell-penetrating peptide with a specific amino acid sequence (YGRKKRRQRRRC), which has the special ability to aid translocation across the plasma membrane, is widely used to modify the anticancer drug carriers, and indeed improve the drug accumulation deep in tumor tissues.
储存指南
一般情况下, TAT 多肽 粉末应该保存在-20甚至-70摄氏度. TAT 多肽 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Shuai Q, Cai Y, Zhao G, Sun X. Cell-Penetrating Peptide Modified PEG-PLA Micelles for Efficient PTX Delivery. Int J Mol Sci. 2020 Mar 9;21(5):1856. doi: 10.3390/ijms21051856. PMID: 32182734; PMCID: PMC7084196.