Recombinant Human TAB1 (TGF-beta-activated kinase 1 and MAP3K7-binding protein 1) fragment (amino acids 1-370) encompassing the full PPM-type phosphatase domain. This high-purity protein is an essential tool for investigating JNK and NF-kappa-B signaling pathways, cytokine production, and TAK1 complex regulation in cellular and biochemical assays.

TAB1 is a critical adapter protein that plays a central role in innate immunity and inflammation by activating both JNK and NF-kappa-B signaling pathways in response to Toll-like receptor (TLR) and cytokine stimulation. It functions by binding to MAP3K7/TAK1's catalytic domain, triggering TAK1 autophosphorylation and full activation, and similarly activates MAPK14 through association. TAB1 also facilitates recruitment of MAPK14 to the TAK1 complex for phosphorylation of TAB2/TAB3 regulatory subunits, while MAPK14-mediated phosphorylation of TAB1 provides feedback inhibition of TAK1 activation. The protein localizes primarily to the cytoplasm and cytosol, wi