Recombinant Gamma-synuclein (SNCG) Fragment (1-95) is a highly stable and soluble protein unit derived from human Gamma-synuclein, optimized for structural and biochemical studies. This fragment supports research into neurofilament and keratin network integrity, as well as MAPK signaling pathways, offering a reliable tool for investigating cellular architecture and cancer-related mechanisms.

Gamma-synuclein, encoded by the SNCG gene in humans, plays a critical role in maintaining neurofilament network integrity and modulating axonal architecture. It enhances the susceptibility of neurofilament-H to calcium-dependent proteases and may regulate the keratin network in skin. Additionally, Gamma-synuclein activates the MAPK and Elk-1 signal transduction pathway, implicating it in cellular signaling processes. The protein is primarily localized in the cytoplasm, particularly in the perinuclear region, and associates with centrosomes during interphase and spindle poles during mitosis, highlighting its involvement in cytoskeletal organization and cell division.