Recombinant Human Stonin-2 (Stoned B) Fragment (aa 426-744) is a high-purity protein designed for studying endocytic machinery and synaptic vesicle recycling. This fragment specifically encompasses the SHD domain, making it an ideal tool for investigating domain-specific functions in clathrin-coated vesicle uncoating and adaptor protein interactions.

Stonin-2 (STON2) is an adapter protein crucial for endocytic processes and synaptic vesicle recycling in human cells. According to functional studies, it facilitates clathrin-coated vesicle uncoating and operates within the endocytic machinery. The protein localizes to the cytoplasm, membrane, and synaptic regions (specifically synaptosomes), with a portion being membrane-associated. This recombinant fragment (426-744) containing the SHD domain (427-560) enables focused research on these specific functional aspects without interference from other protein regions.