- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, IP, WB, IF
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
STMN2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
STMN2 Rabbit Polyclonal antibody. Positive IF detected in SH-SY5Y cells. Positive IHC detected in human medulloblastoma tissue. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue, mouse cerebellum tissue. Observed molecular weight by Western-blot: 18-21kd
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抗体应用
ELISA, IHC, IP, WB, IF
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应用推荐
Recommended Dilution:
WB: 1:1000-1:10000
IP: 1:500-1:5000
IHC: 1:20-1:200
IF: 1:10-1:100
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
Protein SCG10, SCG10, SCGN10, SGC10, Stathmin 2, stathmin like 2, STMN2
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制备方法
This antibody was obtained by immunization of STMN2 recombinant protein (Accession Number: NM_007029). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
STMN2 gene encodes a SCG10 (superior cervical ganglion-10) protein, a regulator of microtubule stability. When phosphorylated by MAPK8, SCG10 stabilizes microtubules and consequently controls neurite length in cortical neurons. SCG10 was early considered a neuron-specific growth-associated protein in Alzheimer’s disease. In the developing brain, SCG10 negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone.
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参考文献
- Shin JE, Miller BR, Babetto E. SCG10 is a JNK target in the axonal degeneration pathway. Proceedings of the National Academy of Sciences of the United States of America. 109(52):E3696-705. 2012.
- Kynast KL, Russe OQ, Möser CV, Geisslinger G, Niederberger E. Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice. Pain. 154(3):368-76. 2013.
- Kallenborn-Gerhardt W, Hohmann SW, Syhr KM. Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity. Pain. 155(10):2161-70. 2014.
- Mukai J, Tamura M, Fénelon K. Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia. Neuron. 86(3):680-95. 2015.
- Islam O, Gong X, Rose-John S, Heese K. Interleukin-6 and neural stem cells: more than gliogenesis. Molecular biology of the cell. 20(1):188-99. 2009.
- Heine S, Michalakis S, Kallenborn-Gerhardt W. CNGA3: a target of spinal nitric oxide/cGMP signaling and modulator of inflammatory pain hypersensitivity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(31):11184-92. 2011.