Recombinant Human Serine/threonine-protein kinase 10 (STK10) fragment (amino acids 1-317) is a high-purity protein encompassing the full protein kinase domain. This product serves as an essential tool for investigating kinase activity, lymphocyte migration regulation, and cell cycle control mechanisms in biochemical and cellular assays.

Serine/threonine-protein kinase 10 (STK10), also known as Lymphocyte-oriented kinase, is a human enzyme (EC 2.7.11.1) that plays a critical role in regulating lymphocyte migration through phosphorylation of ERM proteins such as moesin (MSN). It functions as a negative regulator of MAP3K1/MEKK1 and may act as a cell cycle regulator through potential phosphorylation of PLK1, though in vivo evidence is still required. The protein localizes to the cell membrane as a peripheral membrane protein, positioning it strategically for signal transduction and cellular regulation processes.