- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human, Mouse; other species not tested.
产品详情
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产品名称
SRY antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
SRY Rabbit Polyclonal antibody. Positive WB detected in human testis tissue. Positive IHC detected in human kidney tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 30kd
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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特异性
Human, Mouse; other species not tested.
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蛋白别名
sex determining region Y, SRY, TDF, TDY, Testis determining factor
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制备方法
This antibody was obtained by immunization of SRY recombinant protein (Accession Number: NM_003140). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
SRY (sex-determining region Y protein) is a tran-scriptional activator required for male sex determination in mammals. This protein, also referred to as testis-determining factor (TDF), is an HMG box protein that initiates the formation of testis from undifferentiated gonad. The DNA-binding activity of SRY is required for normal testis formation. This DNA-binding activity is thought to be regulated by PKA, which phosphorylates SRY in vivo. Mutations in SRY have been associated with 46,XY gonadal dysgenesis, in which the gonads fail to develop in XY phenotypic females.