Recombinant Spindlin-4 (SPIN4) fragment (residues 39-249) from Homo sapiens, designed for robust experimental use. This 211-amino acid fragment retains key structural integrity, offering a soluble and stable tool for investigating histone recognition and WNT signaling modulation in cellular processes.

Spindlin-4, encoded by the SPIN4 gene in humans, functions as a histone reader that binds to acetylated and methylated histone marks such as H3K4me3 and H4K20me3. This interaction enables Spindlin-4 to interpret chromatin modifications and mediate downstream cellular effects, including the promotion of canonical WNT signaling and regulation of cell proliferation. The protein localizes to both the cytoplasm and nucleus, underscoring its versatile role in epigenetic regulation and signaling pathways.