Recombinant Human Seven in absentia homolog 3 (Siah-3) Fragment (aa 105-269) is a high-purity protein designed for structural and biochemical studies. This 165-amino acid fragment represents a stable, soluble unit of Siah-3, ideal for investigating its role as a negative regulator of mitochondrial quality control.

Seven in absentia homolog 3 (Siah-3), encoded by the SIAH3 gene in humans, functions as a negative regulator of PRKN translocation to damaged mitochondria. It acts by destabilizing PINK1 protein, thereby inhibiting PRKN targeting to dysfunctional depolarized mitochondria. Siah-3 is localized to the mitochondrion, where it plays a critical role in modulating mitochondrial quality control pathways, with implications for cellular stress responses and neurodegenerative disease mechanisms.