重组食蟹猴ACVR2B蛋白

食蟹猴

人胚胎肾细胞（HEK293）

Ser 28 - Thr 143

A DNA sequence encoding the cynomolgus ACVR2B (EHH16502.1) (Ser28-Thr143) was expressed with the Fc region of human IgG1 at the C-terminus.

> 90 % as determined by SDS-PAGE

Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation.
The ED₅₀ for this effect is typically 10-40 ng/mL in the presence of 10 ng/mL recombinant Activin A.

The recombinant cynomolgus ACVR2B comprises 357 amino acids and has a calculated molecular mass of 40.3 KDa.The apparent molecular mass of the protein is approximately 54-62 KDa in SDS-PAGE.

ACVR2B; ACTRIIB; MGC118477; MGC116908; ACTR-IIB; HTX4

Serine/threonine-protein kinase receptor

ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.