重组恒河猴IL17A蛋白

恒河猴

杆状病毒 - 昆虫细胞

Met 1 - Ala 155

A DNA sequence encoding the rhesus IL17A (XP_001106391.1) (Met1-Ala155) was expressed.

> 95 % as determined by SDS-PAGE.

The recombinant rhesus IL17A consists of 132 amino acids and predicts a molecular mass of 15.1 kDa.

CTLA8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 8; IL-17; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8; INTERLEUKIN-17A; CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED ANTIGEN 8. INTERLEUKIN-17A; INTERLEUKIN 17 (CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED SERINE ESTERASE 8); IL17; IL-17A; CTLA-8

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Lyophilized from sterile 20 mM Tirs, 150 mM NaCl, pH 8.0, 10 % glycerol.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

<1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.