重组恒河猴IFNAR1蛋白

恒河猴

人胚胎肾细胞（HEK293）

Met 1 - Lys 437

A DNA sequence encoding the rhesus IFNAR1 (NP_001253442.1) (Met1-Lys437) was expressed with the Fc region of human IgG1 at the C-terminus.

> 95 % as determined by SDS-PAGE

The recombinant rhesus IFNAR1 comprises 654 amino acids and has a calculated molecular mass of 74.5 KDa.

IFNAR1; CD118; IFN-R-1; AVP; IFAR; INFAR; IFNAR; IFNBR; CRF2-1; IFN-ALPHA-REC; IFRC

Interferon alpha/beta receptor 1

Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due, at least in part, to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1, in which Tyr466 is changed to phenylalanine, can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.