Recombinant Human PYDC1/POP1 Pyrin Domain Fragment (aa 1-89) - A high-purity protein fragment encompassing the complete Pyrin domain, ideal for studying inflammasome regulation and NF-kappa-B signaling pathways in cellular immune responses.

PYDC1 (Pyrin domain-containing protein 1), also known as POP1 or cPOP1, is a key regulatory protein that associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. The protein functions as a suppressor of NF-kappa-B inhibitor kinase (IKK) complex activity, thereby inhibiting NF-kappa-B activation induced by cytokines and LPS, and reducing expression of NF-kappa-B inducible genes. PYDC1 is localized in the cytoplasm, where it is recruited to specks formed by PYCARD, playing a crucial role in inflammasome regulation and inflammatory signaling pathways.