重组小鼠IL11RA蛋白

小鼠

人胚胎肾细胞（HEK293）

Met 1 - Gln 367

A DNA sequence encoding the extracellular domain of mouse IL11R? (NP_001156873.1) (Met 1-Gln 367) was expressed, with a C-terminal polyhistidine tag.

> 85 % as determined by SDS-PAGE

Measured by its ability to bind mouse IL6ST in a functional ELISA.

The secreted recombinant mouse IL11R? consists of 355 amino acids and has a calculated molecular mass of 39.2 kDa. As a result of glycosylation, the apparent molecular mass of rmIL11R? is approximately 45-50 kDa in SDS-PAGE under reducing conditions.

AI314697; MGC2146; IL11RA; IL-11RA; NR1; GP130; IL11RA2; RP23-167I12.2; IL11RA1; HCG_2011440

Putative uncharacterized protein

Interleukin 11 receptor, alpha subunit (IL11RA/IL-11RA) is a subunit of the interleukin 11 receptor which is a member of the hematopoietic cytokine receptor family. IL11RA/IL-11RA is expressed in a number of cell lines, including the myelogenous leukemia cell line K562, the megakaryocytic leukemia cell line Mo7E, the erythroleukemia cell line TF1, and the osteosarcoma cell lines, MG-63 and Saos-2. It is also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus, and three variants encoding two different isoforms have been identified. IL11RA/IL-11RA is a receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. Defects in IL11RA/IL-11RA are a cause of craniosynostosis and dental anomalies (CRSDA). CRSDA is a disorder characterized by craniosynostosis, maxillary hypoplasia, and dental anomalies, including malocclusion, delayed and ectopic tooth eruption, and/or supernumerary teeth. Some patients also display minor digit anomalies, such as syndactyly and/or clinodactyly.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.