PRAME antibody

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  • 抗体类型:多克隆
  • 抗体来源:兔
  • 抗体应用:ELISA, WB, IP
  • 特异性:Human; other species not tested.

产品详情

  • 产品名称
    PRAME antibody
  • 抗体类型
    多克隆
  • 抗体来源
    兔
  • 抗体亚型
    兔IgG
  • 抗体描述
    PRAME Rabbit Polyclonal antibody. Positive IP detected in A549 cells. Positive WB detected in A549 cells, HepG2 cells. Observed molecular weight by Western-blot: 58 kDa
  • 抗体应用
    ELISA, WB, IP
  • 应用推荐

    Recommended Dilution:

    WB: 1:200-1:1000

    IP: 1:200-1:1000

  • 特异性
    Human; other species not tested.
  • 蛋白别名
    MAPE, OIP 4, OIP4, Opa interacting protein 4, PRAME
  • 制备方法
    This antibody was obtained by immunization of PRAME recombinant protein (Accession Number: NM_001291716). Purification method: Antigen affinity purified.
  • 组分
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • 储存方法
    Store at -20℃. DO NOT ALIQUOT
  • 背景介绍
    The PRAME (preferentially expressed antigen of melanoma) gene was previously shown to be overexpressed in ovarian/primary peritoneal serous carcinoma compared with malignant mesothelioma using gene expression arrays. It is considered a melanocyte differentiation antigen which is overexpressed in both solid and hematologic tumors. In normal tissue, a very low level of PRAME expression is found in normal testis, adrenals, ovary and endometrium. A high level of PRAME expression has been reported for several solid tumors, including ovarian cancer, breast cancer, lung cancer and melanomas, medulloblastoma, sarcomas, head and neck cancers, neuroblastoma, renal cancer, and Wilms’ tumor. As a nuclear transcriptional repressor protein, PRAME binds to retinoic acid receptor a, thereby inhibiting retinoic acid induced differentiation, growth arrest, and apoptosis.

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