重组大鼠C10orf54蛋白

大鼠

人胚胎肾细胞（HEK293）

Met 1 - Ala 191

A DNA sequence encoding the rat B7H5 (NP_001037765.1) (Met1-Ala191) was expressed with the Fc region of human IgG1 at the C-terminus.

> 95 % as determined by SDS-PAGE.

The recombinant rat B7H5 consists 397 amino acids and predicts a molecular mass of 44.7 kDa.

B7-H5; STRESS INDUCED SECRETED PROTEIN 1; PLATELET RECEPTOR GI24; PP2135; B7H5; SISP1; GI24; RP11-472K8.3

Platelet receptor Gi24

C10orf54, also known as GI24, belongs to the immunoglobulin superfamily. It is a transmembrane molecule expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESCs, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, C10orf54 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.