Recombinant human Pantothenate kinase 3 (hPanK3) fragment (residues 1-370) is a high-purity protein designed for structural and biochemical studies. This soluble and stable fragment retains the catalytic domain essential for the phosphorylation of pantothenate, enabling research into coenzyme A biosynthesis regulation.

Pantothenate kinase 3 (hPanK3), encoded by the PANK3 gene, catalyzes the phosphorylation of pantothenate to produce 4'-phosphopantothenate, which is the first and rate-determining step in coenzyme A (CoA) synthesis. CoA is a critical cofactor involved in numerous metabolic pathways, including fatty acid metabolism and the citric acid cycle. The full-length protein is localized in the cytoplasm, where it performs its essential role in cellular energy metabolism. This recombinant fragment (residues 1-370) encompasses the functional domain, providing a reliable tool for investigating enzymatic activity and mechanisms in CoA biosynthesis.