This recombinant protein product features a fragment (amino acids 312-476) of human NADPH oxidase activator 1 (NOXA1), encompassing the complete PB1 and SH3 domains. It serves as a specialized tool for investigating the domain-specific mechanisms of NOX1 activation and reactive oxygen species (ROS) production, supporting research in signal transduction, host defense, and oxidative stress pathways.

NOXA1 functions as a key activator of NOX1, a superoxide-producing NADPH oxidase involved in generating reactive oxygen species (ROS). These ROS play critical roles in biological processes such as host defense, hormone biosynthesis, oxygen sensing, and signal transduction. NOXA1 may also activate other NADPH oxidases like CYBB/gp91phox and NOX3. The protein is primarily localized in the cytoplasm and translocates to the cell membrane in a process dependent on NOXO1 or NCF1 and potentially RAC1, facilitating its role in redox signaling and cellular responses.