NCAM1/CD56 antibody

多克隆

兔

兔IgG

NCAM1/CD56 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse cerebellum tissue, rat brain tissue. Positive IHC detected in human colon tissue, human brain tissue, human liver tissue, human lung cancer tissue, human spleen tissue. Positive FC detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 120 kDa, 140 kDa, 180 kDa

ELISA, WB, IHC, FC

Human,Mouse,Rat; other species not tested.

CD56, MSK39, N CAM 1, NCAM, NCAM 1, NCAM1

This antibody was obtained by immunization of NCAM1/CD56 recombinant protein (Accession Number: NM_181351). Purification method: Antigen affinity purified.

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronection-type III repeats (FNIII). All three forms can be posttranslationally modified by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described (PMID: 1856291).

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