Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. A novel peptide myostatin inhibitory peptide 3d displayed an IC50 value of 0.32 μM, which is 11 times more potent than peptide(WRQNTRYSRIEAIKIQILSKLRL-amide). The peptide 3d would have the potential to be a promising drug lead to develop better peptidomimetics.
储存指南
一般情况下, Myostatin inhibitory多肽 3d 粉末应该保存在-20甚至-70摄氏度. Myostatin inhibitory多肽 3d 溶解后应该-70摄氏度分装保存,避免反复冻融. 了解更多细节,请查阅手册:多肽溶解及保存指南
参考文献
Takayama K, Rentier C, Asari T, et al. Development of Potent Myostatin Inhibitory Peptides through Hydrophobic Residue-Directed Structural Modification. ACS Med Chem Lett. 2017;8(7):751-756