- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC, WB, FC, IP
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
MTCO2 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
MTCO2 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in HepG2 cells, HeLa cells, human placenta tissue, mouse brain tissue, mouse liver tissue, rat liver tissue. Positive IHC detected in human colon cancer tissue, human breast cancer tissue. Positive FC detected in HeLa cells. Observed molecular weight by Western-blot: 23-26 kDa
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抗体应用
ELISA, IHC, WB, FC, IP
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应用推荐
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
COII, COX2, COXII, cytOChrome c oxidase II, CytOChrome c oxidase subunit 2, MT CO2, MTCO2
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: YP_003024029). Purification method: Antigen affinity purified.
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组分
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
COX2, also named as COII, COXII and MTCO2, belongs to the cytochrome c oxidase subunit 2 family. It is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Defects in COX2 are a cause of mitochondrial complex IV deficiency (MT-C4D). The antibody is specific to COX2.
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参考文献
- Towheed A, Markantone DM, Crain AT, Celotto AM, Palladino MJ. Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo. Neurobiology of disease. 69:15-22. 2014.
- Mohar I, Stamper BD, Rademacher PM, White CC, Nelson SD, Kavanagh TJ. Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6. Redox biology. 2:377-87. 2014.
- Zhang J, Wang C, Chen X. EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer. The EMBO journal. 34(23):2953-70. 2015.