- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, IHC
- 特异性:Human,Mouse,Rat; other species not tested.
产品详情
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产品名称
MRP5 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
MRP5 Rabbit Polyclonal antibody. Positive IHC detected in human ovary tumor tissue, human pancreas cancer tissue.
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抗体应用
ELISA, IHC
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应用推荐
Recommended Dilution:
IHC: 1:20-1:200
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特异性
Human,Mouse,Rat; other species not tested.
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蛋白别名
ABC33, ABCC5, MOAT C, MOATC, MRP5, pABC11, SMRP
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制备方法
This antibody was obtained by immunization of Peptide (Accession Number: NM_005688). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
ABCC5, also named as MOAT-C, pABC11, SMRP and MRP5, belongs to the ABC transporter superfamily, ABCC family and Conjugate transporter (TC 3.A.1.208) subfamily. ABCC5 acts as a multispecific organic anion pump which can transport nucleotide analogs. ABCC5 functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that ABCC5 provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl) adenine. ABCC5 may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.