Recombinant human Mcl-1 protein fragment (residues 169-327) offers a stable and soluble unit ideal for structural biology and biochemical studies. This fragment, derived from the apoptosis regulator Induced myeloid leukemia cell differentiation protein Mcl-1, is designed to support research on cell survival mechanisms without the complexities of the full-length protein.

Mcl-1 (UniProt ID: Q07820) is a key regulator of apoptosis and cell survival in humans, functioning through interactions with other apoptotic proteins. While isoform 1 inhibits apoptosis, isoform 2 promotes it, highlighting its dual role in cellular viability. The full-length protein localizes to the membrane (as a single-pass protein), cytoplasm, mitochondria, and nucleoplasm, indicating its broad involvement in cellular processes. This recombinant fragment provides a focused tool for investigating Mcl-1's mechanisms in a soluble format, aiding studies on cancer and cell death pathways.