Recombinant Human LYVE-1 (Lymphatic vessel endothelial hyaluronic acid receptor 1) Fragment (aa 20-142) is a high-purity protein designed to encompass the functional Link domain (aa 40-130). This fragment serves as an essential tool for investigating hyaluronan binding, cell adhesion, and lymphatic endothelial-specific mechanisms in a simplified, domain-focused context.

LYVE-1 is a single-pass type I membrane protein in humans that functions as a ligand-specific transporter, mediating trafficking between intracellular organelles and the plasma membrane. It binds hyaluronan (HA) and plays a critical role in autocrine cell growth regulation, HA uptake or transport for catabolism, and facilitation of leukocyte adhesion and migration through lymphatic endothelium. Localized to the plasma membrane, vesicles, and cell-cell junctions, it undergoes ligand-dependent internalization and recycling, highlighting its importance in lymphatic vascular biology and immune cell trafficking.