Recombinant Human Lyn Kinase Fragment (66-512) is a high-purity protein product encompassing the complete SH2 and Protein Kinase domains of Tyrosine-protein kinase Lyn. This fragment serves as an essential research tool for investigating immune signaling pathways, kinase activity, and domain-specific interactions in B-cell regulation, hematopoiesis, and inflammatory responses.

Tyrosine-protein kinase Lyn (encoded by the LYN gene) is a non-receptor tyrosine kinase that plays a pivotal role in regulating innate and adaptive immune responses, hematopoiesis, and cellular signaling pathways. It functions as both a negative regulator and activator depending on cellular context, primarily transmitting signals from immune receptors including B-cell receptors, FC receptors, and Toll-like receptors. Lyn is crucial for B-cell differentiation, proliferation, survival, and immune self-tolerance, while also mediating responses to growth factors, cytokines, and integrin signaling in hematopoietic cells. The protein