LTBP2 antibody

多克隆

兔

兔IgG

LTBP2 Rabbit Polyclonal antibody. Positive WB detected in human testis tissue, mouse testis tissue. Positive IHC detected in human placenta tissue. Observed molecular weight by Western-blot: 240 kDa

ELISA, WB, IHC

Human,Mouse,Rat; other species not tested.

C14orf141, LTBP 2, LTBP2, LTBP3, MSTP031

This antibody was obtained by immunization of LTBP2 recombinant protein (Accession Number: NM_000428). Purification method: Antigen affinity purified.

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

LTBP2, also named as C14orf141, belongs to the LTBP family. Latent TGF-b-binding proteins (LTBPs) were initially identified through their binding to the growth factor. LTBPs have subsequently been found to associate with the extracellular matrix. LTBP2 is an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCEbinding Protein. (PMID: 17581631 )It may play an integral structural role in elastic-fiber architectural organization and/or assembly. LTBP2 associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D). [MIM:613086] LTBP2 is a role in the structural stability of ciliary zonules, and growth and development of lens.(PMID: 20617341) LTBP2 null mutations in an autosomal recessive ocular syndrome with megalocornea, spherophakia, and secondary glaucoma. (PMID: 20179738 ) LTBP2 is a biomarker of Heart failure.

• Bai Y, Zhang P, Zhang X, Huang J, Hu S, Wei Y. LTBP-2 acts as a novel marker in human heart failure - a preliminary study. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 17(5):407-15. 2012.
• Ren Y, Lu H, Zhao D. LTPB2 acts as a prognostic factor and promotes progression of cervical adenocarcinoma. American journal of translational research. 7(6):1095-105. 2015.