Recombinant Receptor-like tyrosine-protein kinase kin-15 (EC 2.7.10.1) fragment (residues 127-488), encompassing the full Protein kinase domain (144-458), is designed for targeted investigation of kinase activity and cell-cell interaction mechanisms in Caenorhabditis elegans. This high-purity fragment serves as an essential tool for domain-specific functional studies.

The full-length Receptor-like tyrosine-protein kinase kin-15 in Caenorhabditis elegans plays a critical role in postembryonic development by mediating cell-cell interactions that regulate hypodermal cell fusions, particularly in the formation of the HYP7 hypodermal syncytium. As a single-pass membrane protein localized to the cell membrane, it is integral to signaling pathways governing tissue syncytium development. The provided fragment enables focused research on the functional kinase domain without interference from transmembrane regions.