产品详情
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产品名称
重组人KIF5C蛋白
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蛋白种属
人
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表达宿主
大肠杆菌
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蛋白序列
MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQEQVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAVPEDELEHHHHHH
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克隆构建
DNA encoding 1-380 aa (O60282) were fused with C-terminal 6His tag.
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蛋白纯度
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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蛋白活性
Not tested.
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分子量
Predictes a molecular mass of 43.91 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 48 kDa band.
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蛋白全名
Kinesin heavy chain isoform 5C
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蛋白描述
Recombinant Kinesin heavy chain isoform 5C (KIF5C) fragment (amino acids 1-380), encompassing the complete kinesin motor domain. This high-purity human protein is ideal for investigating microtubule-associated force production, ATPase activity, and motor function in neuronal transport and organelle dynamics.
Kinesin heavy chain isoform 5C (KIF5C) is a microtubule-associated force-producing protein involved in ATP-dependent organelle transport and synaptic transmission. It mediates dendritic mRNA trafficking and is required for anterograde axonal transport of proteins like MAPK8IP3/JIP3, crucial for axon elongation. The protein localizes to the cytoplasm, cytoskeleton, and dendrites, with abundance in distal dendritic regions, highlighting its role in neuronal polarity and intracellular logistics.
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发货形式
Lyophilized from sterile PBS, pH 7.4
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内毒素
Please contact the lab for more information.
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保存条件
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.