KEMPFPKYPVEP is a peptide identified from a screen of digested casein protein for the ability to improve spatial memory in amnesia mouse models. KEMPFPKYPVEP peptide was found to prevent scopolamine induced deficit in short term spatial memory, and also enhance long term object recognition memory in intact mice, with increased levels of dopamine and norepinephrine, but not serotonin being found in the frontal cortex. Previous epidemiological investigations have indicated that consuming dairy products can prevent cognitive decline, however only cheese fermented with fungi contains the KEMPFPKYPVEP peptide, which is found at the highest level in Camembert at 14.58-39.02 pmol per gram.
Ano et al (2019) Identification of a Novel Peptide from β-Casein That Enhances Spatial and Object Recognition Memory in Mice. J Agric Food Chem. 67(29) 8160 PMID: 31241932