重组人IL18RAP蛋白

人

人胚胎肾细胞（HEK293）

Met 1 - Gly 357

A DNA sequence encoding the human IL18RAP (NP_003844.1) (Met 1-Gly 357) was fused with the Fc region of human IgG1 at the C-terminus.

> 95 % as determined by SDS-PAGE

The recombinant human IL18RAP/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 575 amino acids and has a calculated molecular mass of 65.2 kDa. As a result of glycosylation, the apparent molecular mass of rhIL18RAP/Fc monomer is approximately 80-90 kDa in reduced SDS-PAGE.

IL-18RACP; CDW218B; IL-18 RECEPTOR ACCESSORY PROTEIN; IL-1R-7; IL-1R7; IL-18RBETA; IL-18R-BETA; ACPL; CD218 ANTIGEN-LIKE FAMILY MEMBER B; ACPL ACCESSORY PROTEIN-LIKE; IL-1RACPL; CD218B; IL18RB; MGC120589

Interleukin-18 receptor accessory protein

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the aetiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.

Lyophilized from sterile PBS, pH 7.4
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.