Recombinant Human Zinc Finger Protein Helios (IKZF2) Fragment (105-219) is a highly stable and soluble protein fragment designed for structural and biochemical studies. This product offers researchers a reliable tool to investigate the functional domains of Helios, a key transcriptional regulator in the Ikaros family essential for hearing development and T-cell function.

Zinc finger protein Helios, encoded by the IKZF2 gene, functions as a transcriptional regulator critical for the maturation of outer hair cells (OHCs), which is necessary for hearing. It localizes to the nucleus and associates with Ikaros at centromeric heterochromatin in T-cell nuclei, highlighting its role in gene regulation and cellular differentiation. The full-length protein's involvement in these processes underscores its importance in auditory health and immune system function, making it a valuable target for research in developmental biology and immunology.