重组人PPM1D蛋白

产品详情

  • 产品名称
    重组人PPM1D蛋白
  • 蛋白种属
    人
  • 表达宿主
    大肠杆菌
  • Unitprot ID
    A0A8J9C7E3
  • 蛋白序列
    254-423
  • 克隆构建
    A DNA sequence encoding the human PPM1D (NP_003611.1) 254-423 aa was fused with the polyhistidine tag
  • 蛋白活性
    Not tested.
  • 蛋白别名
    WIP1
  • 蛋白全名
    Protein phosphatase 1D
  • 蛋白描述
    Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (PubMed:21283629). {PubMed:15870257, PubMed:16311512, PubMed:21283629}.
  • 发货形式
    Protein lyophilized in sterile PBS (58 mM Na2HPO4, 17 mM NaH2PO4, 68 mM NaCl, 300 mM Imidazole, pH 8.0). Trehalose (5-8%) and mannitol (5-8%) protectants were added before lyophilization.
  • 内毒素
    Please contact the lab for more information.
  • 保存条件
    Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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