重组人IGF1蛋白

人

大肠杆菌

A DNA sequence encoding the Human IGF1/IBP1 Thr52-Ala118 is expressed.

>95% as determined by SDS-PAGE.

IBP1

insulin like growth factor 1(IGF1)

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.

Lyophilized from a 0.2 μm filtered solution of 300mM NaAc, pH 6.5.

<0.5 EU per μg protein as determined by the LAL method.

Lyophilized protein should be stored at <-20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.