重组人ERBB2蛋白

人

人胚胎肾细胞（HEK293）

Pro 489 - Cys 630

A DNA sequence encoding the human ERBB2 (AAA75493.1) (Pro489-Cys630) was expressed with a polyhistidine tag at the C-terminus.

> (48.9+40.2) % as determined by SDS-PAGE.

The recombinant human ERBB2 consists of 153 amino acids and predicts a molecular mass of 17.1 kDa.

TKR1; C-ERBB2; HER-2/NEU; ERBB-2; C-ERBB-2; CD340; MKIAA3023; HER2; NGL; NEU; MLN19; ERBB2; RP23-355L10.8; C-NEU; HER-2

Receptor tyrosine-protein kinase erbB-2

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

Lyophilized from sterile PBS, pH 7.4.
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

<1.0 EU per μg protein as determined by the LAL method.

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.