重组人AGRP蛋白

人

人胚胎肾细胞（HEK293）

Met 1 - Thr 132

A DNA sequence encoding the human AgRP (NP_001129.1) (Met 1-Thr 132) was expressed with the fused Fc region of human IgG1 at the C-terminus.

> 97 % as determined by SDS-PAGE

The recombinant human AgRP/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 350 amino acids and predicts a molecular mass of 39 kDa also estimated by SDS-PAGE under reducing conditions.

AGRT; MGC118963; ASIP2; AGRP; ART

Agouti related protein homolog (Mouse)

Agouti Related Protein (AGRP, or AGRT), is an endogenous antagonist of the melanocortin receptors MC3R and MC4R found in the hypothalamus and exhibits potent orexigenic activity. AGRP can act as a competitive antagonist to proopiomelanocortin (POMC)-derived peptides at the melanocortin-4 receptor (MC4R), and that this homeostatic mechanism is important as a means of coordinating appetite with perceived metabolic requirement. AGRP is upregulated by fasting while intracerebroventricular injections of synthetic AGRP lead to increased appetite and food intake. Thus, AGRP is a powerful orexigenic peptide that increases food intake when ubiquitously overexpressed or when administered centrally.

Lyophilized from sterile PBS, pH 7.2
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

< 1.0 EU per μg of the protein as determined by the LAL method

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.