- 抗体类型:多克隆
- 抗体来源:兔
- 抗体应用:ELISA, WB, IHC
- 特异性:Human, Mouse, Pig; other species not tested.
产品详情
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产品名称
HNRNPA1 antibody
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抗体类型
多克隆
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抗体来源
兔
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抗体亚型
兔IgG
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抗体描述
HNRNPA1 Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells, HeLa cells, mouse colon tissue. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 34kd
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抗体应用
ELISA, WB, IHC
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应用推荐
Recommended Dilution:
WB: 1:200-1:1000
IHC: 1:20-1:200
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特异性
Human, Mouse, Pig; other species not tested.
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蛋白别名
Helix destabilizing protein, hnRNP A1, hnRNP core protein A1, HNRNPA1, HNRPA1
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制备方法
This antibody was obtained by immunization of HNRNPA1 recombinant protein (Accession Number: NM_002136). Purification method: Antigen affinity purified.
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组分
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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储存方法
Store at -20℃. DO NOT ALIQUOT
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背景介绍
In eukaryotic cells, nascent RNA polymerase II transcripts are associated in the nucleus with specific proteins to form ribonucleoprotein complexes called HNRP or 40S. Protein moiety of the HNRP particle has 6 major components called core proteins, and HNRPA1 is one of them. hnRNP A1 is a multifunctional RNA binding protein which is involved in pre-mRNA splicing, export of mature transcripts from the nucleus, mRNA turnover, and internal ribosome entry site (IRES)-mediated translation. HNRNPA1 has three isoforms with MW 30 kDa, 34 kDa and 39 kDa.
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参考文献
- Guo R, Li Y, Ning J, Sun D, Lin L, Liu X. HnRNP A1/A2 and SF2/ASF regulate alternative splicing of interferon regulatory factor-3 and affect immunomodulatory functions in human non-small cell lung cancer cells. PloS one. 8(4):e62729. 2013.
- Chen K, Huang C, Yuan J, Cheng H, Zhou R. Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells. Molecular biology and evolution. 31(8):2194-211. 2014.
- Markus MA, Marques FZ, Morris BJ. Resveratrol, by modulating RNA processing factor levels, can influence the alternative splicing of pre-mRNAs. PloS one. 6(12):e28926. 2011.
- Lu Q, Bai J, Zhang L. Two-dimensional liquid chromatography-tandem mass spectrometry coupled with isobaric tags for relative and absolute quantification (iTRAQ) labeling approach revealed first proteome profiles of pulmonary alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. Journal of proteome research. 11(5):2890-903. 2012.