重组人HSPA8蛋白

人

大肠杆菌

Met 1 - Asp 646

A DNA sequence encoding the human HSPA8 (P11142-1) (Met 1-Asp 646) was expressed, with a polyhistide tag at the N-terminus.

> 90 % as determined by SDS-PAGE

The recombinant human HSPA8 consisting of 657 amino acids and has a calculated molecular mass of 72.4 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions.

HSP71; HSC71; HSP73; HEL-33; HEL-S-72P; HSC70; MGC131511; HSC54; MGC29929; LAP1; HSPA10; MGC114311; LAP-1; NIP71; 2410008N15RIK; HSC73; HSPA8

Heat shock cognate 71 kDa protein

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase CHIP.

Lyophilized from sterile PBS, 10% glycerol, pH 7.5
1. 5 % trehalose and mannitol are added as protectants before lyophilization.
2. Please contact us for any concerns or special requirements.

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Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.